Pharmaceutics, Vol. 10, Pages 9: Is the Skin Absorption of Hydrocortisone Modified by the Variability in Dosing Topical Products?
Pharmaceutics doi: 10.3390/pharmaceutics10010009
Fingertip units have been proposed as a tool to standardize topical therapy with semisolid formulations. However, no studies to date have characterized the variability in dosing by patients using this concept and whether this variability ultimately affects the topical absorption of drugs. This work aimed to answer these two questions. A first study determined the dose measured, the area of spread and the area-normalized dose for a 1% hydrocortisone cream and ointment applied by …read more